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KMID : 0359420050230010071
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Korean Journal of Sports Medicine
2005 Volume.23 No. 1 p.71 ~ p.77
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Comparison of the Relative Frequencies of the Angiotensin-Converting Enzyme Gene Polymorphism in Trained High-School Athletes and General Students
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Woo Sang-Koo
Han Tae-Kyung
Kang Hyun-Sik
Kim Chang-Hwan
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Abstract
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The purpose of this study was to investigate the allele and genotype frequencies of the angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism in highly trained high-school athletes and general students. A total of 215, of which 117 were enrolled athletes and 98 were enrolled as students in either K high-school or J high-school, participated in the study. The athletes were further classified into either aerobic(n=30) or anaerobic(n=87) athletes. A commercially available-sterilized cotton swap was used to collect buccal cells, which was used to extract human genomic DNA using the QiaAmp DNA Blood Mini Kits (Qiagen, CA, USA). Polymerase-Chain Reaction (PCR) combined with 2% agarose gel electrophoresis and ethidium bromide staining was used for the ACE insertion/deletion genotyping. χ2 and Bonferroni post-hoc analyses were used to test any significant differences in the relative frequencies of alleles and genotypes 1) between the athletes and the general students and 2) among the aerobic athletes, the anaerobic athletes and the general students at p = .05. Comparison between the athletes and the general students showed no significant group difference in the relative frequency of the II genotype. Further analysis for the sub-group (aerobic vs. anaerobic athletes) of the athletes showed that the aerobic athletes had a significantly higher frequency of the II genotype (33.3%) than either the anaerobic athletes (19.5%) or the general students (16.3%) at p = .041 and p = .042, respectively. In conclusion, the current finding of the study suggests that the II genotype of the ACE gene polymorphism may be a genetic marker of the aerobic capacity for an endurance athletes.
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KEYWORD
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Angiotensin-converting enzyme, ACE, ACE I/D gene polymorphism, Aerobic and anaerobic capacity, Polymerase chain reaction
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